Big Daddy uses its brute strength to fight, either by using its fist or drill. He is difficult to face up close to due armored attacks. Big Daddy is also able to use Plasmids, similar to the Alpha series of Big Daddies and Subject Delta, another Big Daddy, and the protagonist of BioShock 2. Big Daddy's Plasmids allow Big Daddy to attack at a mid-range, but Big Daddy's strongest area in close-quarters combat. His attacks are not easily interrupted and they offer many ways to combo. A trade for Big Daddy's strength is low running speed. He has few options for closing in on opponents but he does have Charging Rush which cannot be interrupted by a single regular attack due to Super Armor and can move Big Daddy in at quick speeds. Big Daddy's best game mode in generally said to be 1V1 but he does have attacks capable of hitting crowds such as Drill Slam.
- Jab - - A simple punch.
- Overhead Palooka - or + - Big Daddy does a downward punch, knocking enemies to the ground.
- Uppercut - + - A simple uppercut.
- Sweeping Fist - + - Big Daddy does a swinging punch.
- Aerial Jab - (Air) - Same as the ground version.
- Aerial Hard Punch - or + (Air) - Big Daddy does a stronger punch, sending enemies away.
- Aerial Uppercut - + (Air) - Same as the ground version.
- Aerial Down Punch - + (Air) - Big Daddy does a downward punch.
- Drill Punch - - Big Daddy quickly thrusts its drill, knocking foes down.
- Charging Rush - or + - Big Daddy dashes forward, stopping only when striking an opponent. If the charge connects, Big Daddy slams its opponent down with an overhead swing of the drill arm.
- Drill Skewer - + - Big Daddy does a multi-hit uppercut with its drill.
- Drill Slam - + - Big Daddy smashes the drill into the ground, causing explosions. Can be mashed to cause more explosions, eventually sending the opponent away.
- Aerial Drill Punch - (Air) - Same as the ground version.
- Aerial Charging Rush - or (Air) - Same as the ground version.
- Aerial Drill Skewer - + (Air) - Same as the ground version.
- Descending Drill Slam - (Air) - Same as the ground version, only Big Daddy falls to the ground, creating a massive explosion when it hits the floor. Can be mashed to create more explosions.
- Incinerate! - - Big Daddy unleashes a small explosion from its hand. Hold button to unleash a bigger explosion that knocks the opponent away.
- Electro Bolt - or + - Big Daddy fires a bolt of electricity, stunning the opponent on contact.
- Cyclone Trap - + - Big Daddy summons a tornado that launches the opponent into the air.
- Winter Blast - + - Big Daddy creates a small patch of ice on the ground, freezing the opponent temporarily.
- Air Incinerate - (Air)
- Air Electro Bolt - or + (Air)
- Air Cyclone Trap - + (Air)
- Air Winter Blast - + (Air)
- Drill Forward Eject - or - Big Daddy holds the opponent with one hand, and knocks them away using its drill.
- Drill Up Eject - - Big Daddy grabs the opponent and knocks them into the air using its drill.
- Slam - - Big Daddy grabs the opponent and slams them into the ground.
Little Sister Gather- Big Daddy roars, calling forth a Little Sister to stab the target to attempt to drain its ADAM.
Frenzy- Big Daddy enters an enraged state, increasing its speed and agility and allowing its attacks to kill.
Flood- The entire stage is flooded with water. Big Daddy is free to pick them all off, even as they try to swim away.