Big Daddy uses its brute strength to fight, either by using its fist or drill. He is difficult to face up close to due armored attacks. Big Daddy is also able to use Plasmids, similar to the Alpha series of Big Daddies and Subject Delta, another Big Daddy, and the protagonist of BioShock 2. Big Daddy's Plasmids allow Big Daddy to attack at a mid-range, but Big Daddy's strongest area in close-quarters combat. His attacks are not easily interrupted and they offer many ways to combo. A trade for Big Daddy's strength is low running speed. He has few options for closing in on opponents but he does have Charging Rush which cannot be interrupted by a single regular attack due to Super Armor and can move Big Daddy in at quick speeds. Big Daddy's best game mode in generally said to be 1V1 but he does have attacks capable of hitting crowds such as Drill Slam.
- Jab - - A simple punch. Can be repeated.
- Overhead Palooka - or + - Big Daddy does a downward punch, knocking enemies to the ground. Hits twice.
- Uppercut - + - A simple uppercut.
- Sweeping Fist - + - Big Daddy swings his fist downwards.
- Aerial Jab - (Air)
- Aerial Hard Punch - or + (Air) - Big Daddy does a much stronger punch, sending enemies away from him.
- Aerial Uppercut - + (Air)
- Aerial Down Punch - + (Air) - Big Daddy does a punch while falling downwards.
- Drill Punch - - Big Daddy quickly thrusts his drill, knocking foes down.
- Charging Rush - or + - Big Daddy dashes forward, stopping only when striking an opponent. If the charge connects, Big Daddy slams his opponent down with a swing of the drill arm.
- Drill Skewer - + - Big Daddy does a multi-hit uppercut with his drill.
- Drill Slam - + - Big Daddy smashes the drill into the ground, causing explosions. Can be mashed to cause more explosions, eventually sending the opponent away.
- Aerial Drill Punch - (Air)
- Aerial Charging Rush - or (Air)
- Aerial Drill Skewer - + (Air)
- Descending Drill Slam - (Air) - Big Daddy falls to the ground, creating a massive explosion when he hits the floor. Can be mashed to create more explosions.
- Incinerate! - - Big Daddy unleashes an explosion from his hand, launching enemies away.
- Electro Bolt - or + - Big Daddy fires a short-ranged bolt of electricity, shocking foes on contact.
- Cyclone Trap - + - Big Daddy summons a tornado that launches opponents into the air.
- Winter Blast - + - Big Daddy creates a patch of ice on the ground, freezing foes.
- Air Incinerate - (Air)
- Air Electro Bolt - or + (Air)
- Air Cyclone Trap - + (Air)
- Air Winter Blast - + (Air)
- Drill Forward Eject - or - Big Daddy holds the opponent with one hand, then drills them, sending them away.
- Drill Up Eject - - Big Daddy slams the opponent into the air with his drill.
- Slam - - Big Daddy grabs the opponent, then slams them into the ground.
Little Sister Gather- Big Daddy roars, calling forth a Little Sister to stab the target to attempt to drain its ADAM.
Frenzy- Big Daddy enters an enraged state, increasing its speed and agility and allowing its attacks to kill.
Flood- The entire stage is flooded with water. Big Daddy is free to pick them all off, even as they try to swim away.